Can You Take Sam-E and Nac Together – Complete Guide!

Can You Take Sam-E and Nac Together

When consuming an antidepressant, you might want to mix it up for better proficiency. Mixing it up could affect you in a different way. Consider what will happen if you take NAC and SAMe at the same time.

So, can you take sam-e and nac together?

Yes, if you want you can take NAC and SAMe at the same time. Both of them do the same thing. NAC works at the beginning of the methylation cycle. SAMe on the other hand, operates at the tail end of the cycle. Just use them together in small dosages at the start. Later, increase the dosage as necessary.

Now that was a glimpse of the whole article. If you want to know more about this matter, this article should be helpful to you.

What is Same-e?

What is Same-e?

S-Adenosylmethionine is a naturally occurring substance that can be found in every tissue in the body. It is engaged in several essential processes. It is necessary for our immune system. It also aids in the generation and breakdown of hormones and helps to maintain cell membranes.

SAMe is usually combined with vitamin B12 or folate. A lack of vitamin B12 or folate may lower SAMe levels in the body.

SAMe inhibits uncontrolled cell division, which is a hallmark of cancer cells. It also inhibits MMP, an enzyme that has been linked to cancer development.

SAMe is required by the brain to produce serotonin, dopamine, and noradrenaline. These hormones are beneficial to mood, motivation, and general mental wellness.

It protects cells from oxidative stress affecting our bodies by increasing synthesis of glutathione, a master antioxidant.

What Is Same-E Used For?

What Is Same-E Used For

SAMe is used to treat a wide range of medical conditions. According to the findings, SAMe aids in the treatment of depression. It also helps with arthritic pain in many circumstances. Recently, researchers were able to investigate the effects of SAMe given orally. Some of the uses of SAMe are discussed below.

1. Depression

SAM-e is one of the most extensively researched alternative remedies for depression. It works faster than traditional antidepressants and produces comparable outcomes. Antidepressants often take 6 to 8 weeks to begin working. SAMe, on the other hand, appears to begin acting sooner.

SAMe is beneficial for patients who do not respond well to prescription antidepressants. When used with other antidepressants, it can be beneficial.

2. Osteoarthritis

A number of well-designed research indicate that SAMe may alleviate joint discomfort and inflammation. These studies also suggest that it may aid in cartilage healing. In some short-term experiments, SAMe supplements were equally effective as nonsteroidal medicines.

SAMe mostly aided persons suffering from knee, hip, or spine osteoarthritis in lowering morning stiffness. It also helped with discomfort and swelling, enhancing range of motion, and boosted walking speed.

3. Fibromyalgia

SAMe has been shown to be useful in lowering fibromyalgia symptoms. Pain, weariness, morning stiffness, and a low mood are among the symptoms. However, the majority of research employed an injectable version of SAMe.

4. Liver Disease

People with liver illness frequently are unable to produce SAMe in their bodies. Preliminary research indicates that consuming SAMe may aid in the treatment of chronic liver damage.

How Much To Take?

SAMe dosages are recommended according to the patient’s condition. The following list details the doses used in trials for each condition:

  • Depression – 800 to 1,600 mg SAMe each day, split into two doses.
  • Osteoarthritis – 600 to 1,200 mg daily, divided into two or three doses.
  • Fibromyalgia – For 6 weeks, take 400 mg twice every day.
  • Liver Disease – For 6 months, take 600 to 1,200 mg per day in divided doses. 

What Are The Available Forms?

SAMe is available in the form of pills or capsules. They should be kept cold and dry, but not frozen. Tablets should be maintained in their blister pack until used.

What Are The Precautions?

Taking SAMe may have unintended consequences. It is usually preferable to use dietary supplements under the guidance of a physician.

A large dosage of SAMe might cause mania. So always start on a low dose. Pregnant women sound not take SAMe. This supplement should also be avoided by those who have bipolar disorder. Without first contacting your doctor, do not take SAMe with other antidepressants.

What Are Possible Interactions?

Taking SAMe alongside certain medications may raise the risk of serotonin syndrome. You should not use these medications without first consulting with your doctor. These drugs are:

  • Dextromethorphan
  • Meperidine
  • Tramadol
  • Pentazocine

SAMe has the chance to react badly to other antidepressants. So while taking any other anti-depressants, it’s better not to use SAMe. It also can reduce the effectiveness of Parkinson’s disease medications.

You can take SAMe while using steroids. There aren’t any possible interactions between them. However, it is best not to take them when on a long steroid cycle.

What Is Nac?

What Is Nac

Cysteine is an amino acid, which is a protein-building block found throughout the body. It is commonly taken as a supplement in the form of N-acetyl-L-cysteine.

NAC can help reduce adverse effects from medication interactions and hazardous substances. It can also aid in the breakdown of mucus in the body. It appears to be beneficial in the treatment of several respiratory disorders.

What Is Nac Used For?

Many medical disorders can be prevented or treated with NAC. These medical conditions will be discussed below.

1. Acetaminophen poisoning

People who have had an acetaminophen overdose are frequently given intravenous (IV) NAC. This aids in the prevention or reduction of liver and kidney damage. Acetaminophen poisoning can occur at lower dosages if someone consumes alcohol.

2. Angina

NAC combined with nitroglycerin can be more helpful in relieving chest discomfort than either one alone. The combination, however, might result in a severe headache. You should not attempt to cure chest discomfort yourself. Always seek medical advice.

3. Chronic bronchitis and chronic obstructive pulmonary disease (COPD)

Taking NAC can help people who are sick with COPD. The usage of NAC decreases the chance of flare-ups. 

How Do You Take It?

NAC dosages vary based on the health issue being treated. Consult your doctor to establish the best NAC dose for your specific condition.

What Are The Available Forms?

NAC is available in multiple forms. You can get NAC as an aerosol spray or tropical solution. It is also available as liquid NAC. It is also available as a powder and tablets. 

What Are The Precautions?

Because of the possibility of negative effects, it’s best to use dietary supplements with caution. The following toxic forms of cysteine should be avoided when taking NAC:

  • D-cysteine
  • 5-methyl cysteine
  • D-cystine

NAC may elevate homocysteine levels. Check your homocysteine level if you are using NAC.

Extremely high amounts of cysteine may be harmful to human cells and can cause death. NAC also shouldn’t be taken orally. It can cause nausea and vomiting.

What Are Possible Interactions?

There are some medications that you shouldn’t use with NAC. If you have to use these, talk to your doctor first. These can be considered NAC supplement dangers. These medications are:

  • Immunosuppressant medications
  • Nitroglycerin and isosorbide
  • Oxiconazole
  • Activated Charcoal

Using NAC can decrease the number of creatine levels in subjects with normal kidney function. You can take clumpy creatine when this happens. Just don’t overdo it.

Can You Take Them Together?

can you take sam-e and nac together

SAMe and NAC are both very similar anti-depressants. Both of them feed into the methylation cycle. NAC supplies ingredients at the start of the cycle. SAMe, on the other hand, is a step or two from the ultimate product glutathione.

As it operates near the conclusion of the cycle, SAMe may have considerably more significant effects. Some avoid it since it might create manic symptoms, but others find it quite beneficial for depression.

So if you want, you can take SAMe and NAC at the same time. But it’s better to start in reduced dosage in the beginning. You can gradually raise the dosage as you become accustomed to the drug.


  • Can Sam-E Make You Tired?

SAMe’s most prevalent negative effects were nausea and other digestive problems. It can sometimes be anxiousness. However, there is no record of anyone being weary from using SAMe.

  • Can You Take Nac Long-Term?

Long-term NAC administration can minimize the likelihood of exacerbations in bronchiectasis patients. To be on the safe side, do not use it on children. When used orally, NAC is most likely safe. The dosages range from 900 to 2700 mg daily for up to 12 weeks.

  • Can You Take Glutathione And Nac Together?

Yes, you may take both of these at the same time. NAC and glutathione both improve immunological function. According to research, boosting glutathione with NAC may enhance and restore immunological function. This aspect has received the greatest attention among HIV patients.

  • When To Take Nac, Morning Or Night?

NAC has the chance to disturb the sleep cycle. As a result, it is preferable to take NAC in the morning rather than at night. NAC should be taken on an open stomach early in the morning.


Now you know the answer to can you take sam-e and nac together. Both of them are antidepressants. They also work in the same way. 

Just remember to take it in a reduced dosage in the beginning. Before using these supplements, consult with your doctor. I hope this essay answered your questions.

Have a wonderful day!

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