Letro and Nolva for Gyno: Which Is the Best Alternative?

As a bodybuilder, it gives you itchy when you see your puffy nipple area. You are searching for surgery alternatives for this problem, also known as Gynecomastia. 

At last, you found some medicine named letro and nolva. But exactly what is letro and nolva for gyno, and how does this medicine function?

Letro and Nolva are the abbreviations of Letrozole and Nolvadex, respectively. Both are non- steroids medicines used for the reduction of gyno. The purpose is the same. But these two drugs function differently, and have side effects and benefits. Letro is an AI drug, while Nolvadex is a SERM.

That was only a small part of the whole article. To know all the details about these drugs, read the entire article.

What is Gyno And How to Remove It?

Gynecomastia is the formation of the nipple in men. It can cause the chest and nipple area to be puffy, bloated, and breast-like.

 The illness is typically not harmful. But it can create social and psychological hardship in persons who have it. 

 Best Option to Reduce Gyno

surgery is the best option to reduce gyno. There are two main options available to reduce gyno: surgery and medicine.

 Medicine like letrozole and Nolvadex is mainly used to control fat. It does not entirely remove it.

 But surgery permanently removes the gyno from the body. Consult with your doctors before choosing any option.

I know you are more curious about the relationship between gyno and bodybuilding. But That’s all about it from gyno.

 Now let’s jump to the main topic!

Letro And Nolva: Quick Overview 

To give a quick understanding, we provide a quick overview of the situation. Have a look at it. 

Particulars Letro Nolva 
Benefits Lower estrogen level and water retention Control estrogen hormones in specific areas reduce stress.
Side Effects Headaches, anxiety, blurred vision, sweating, nausea, dry lips, and increased cholesterol levels.
rattling breathing, painful, pale skin, weight gain, liver damage, blood clots, low libido, mood swings
Daily Usage2.5 mg daily.Nolvadex is typically taken at 40 mg daily for the first 2 weeks of a PCT.  And then reduced to 20mg daily for the final 2 weeks
Disease Interactionliver disease, Cholesterol, osteoporosis DVT/pulmonary embolism, endometrial dysplasia, hepatic dysfunction, Myelosuppression, visual disturbances
Food InteractionsAlcohol Soy products, alcohol
Price $(125-135)  for 30 tablets for 2.5 mgThe general price for Nolvadex is between £25 – £35 per box containing 10mg.

Letro and Nolva: Detailed Overview


Nolvadex is perhaps the most popular anti-estrogen available. It developed almost 50 years ago. It is highly effective in blocking Estrogen’s action in target tissues like breast tissue 

Nolvadex is also recognized as Tamoxifen and SERM ( Selective Androgen Receptor Modulator). Nolvadex, unlike Aromasin or Arimidex, does nothing to reduce the degree of aromatization in the body. 

Letrozole can reduce your total estrogen levels. Since it inhibits the aromatase enzyme. Serm exclusively attacks particular regions of the body. Letrozole can now counteract a wider variety of estrogenic adverse effects from steroids.


Nolvadex is commonly used to decrease estrogenic activity in breast tissue to avoid gynecomastia. However, it will not ultimately reduce the potential of gyno. Researchers discovered a drop in the body mass index of 30.5 and 35.5.

They also found the improvement of physiological markers, including resting cardiac heart rate, glycerol, and HDL. Aside from that, Nolvadex did not affect the occurrence of excess glucose or insulin. Instead, it accelerates the pace of body fat removal.

A stress hormone called Cortisol makes us feel anxious and worried. Cortisol also naturally decreases testosterone synthesis. Nolva can assist in minimizing cortisol production. Hence it can help to reduce stress and enhance relaxation time.

Gynecomastia and water retention are the two most common applications for letro ones. This will also assist in avoiding high blood pressure.

Letrozole lowers the total circulating estrogen balance in the bloodstream. Letrozole is also effective in controlling water retention. We all wish to prevent the second significant side effect of steroid usage.

Because Letrozole is the most effective AI available right now. It may cause your estrogen levels to drop too low. 


Side Effects 

Hair loss, joint discomfort, nausea, diarrhea, and sleeping issues are the Letrozole side effects gyno. Consult the doctor as quickly as possible if either of these adverse effects persists or worsens.

The nolvadex for gyno side effects are as follows:

  • Bone and joint discomfort;
  • Immunity deteriorates
  • Catabolic processes have been accelerated (your gains start to vanish)
  • Depression, weariness, and a lowered libido

Remember, the doctor has suggested any medication believing the usefulness exceeds the risk of side effects. The vast majority of people who use this medication experience no significant side effects.

However, we have some supplements to recommend in case you do face the side effects.

FLEXOBLISSThis supplement ensures the health of your back muscles and bones to keep you flexible and active.
IMMUNITY 911This supplement ensures a high immune system. It can boost your body’s ability to protect itself from viruses, diseases and aging. 

Daily Usage

We assume you have an idea about steroids weekly cycles. Otherwise, you will get confused between medical usage and the PCT part.

We must look at the dose information before using Nolvadex. (10 – 20)mg per day is indicated for medicinal purposes.

However, for PCT reasons, Nolvadex should have been administered for 4 weeks. For the first week, It should be taken at 40mg of tamoxifen for gyno.

 It should be taken in doses of 20mg per day during weeks 2 and 3. and 10mg per day during week 4.

The letrozole dosage for gyno should be taken every 2 or 3 days. Orally, with plenty of water. Letro should be taken on an empty stomach.

2.5 mg daily is the medical prescription treatment. However, a dosage of as little as 0.5mg to 1.25mg every two days is frequently sufficient for most men.

Disease Interaction

The liver substantially metabolizes letrozole. Letrozole tablet usage may result in a reduction in bone mineral density (BMD).

 Individuals at risk for osteoporosis, such as elder people, should be prescribed with precaution. Consider assessing bone mineral density in individuals using letrozole.

Thrombocytopenia, leukopenia, and anemia are all possible side effects of tamoxifen treatment. Tamoxifen has been linked to corneal abnormalities, cataracts, and retinopathy. 

Tamoxifen is processed extensively by the liver and eliminated in the feces. Changes in liver enzyme activity have been observed.

Food Interaction

52.3 per cent of letrozole patients and 28.6 per cent of tamoxifen users had hypercholesterolemia. CTC score hypercholesterolemia was seen in 0.4% and 0.1% respectively, letrozole and Nolvadex patients. 

Before combining tamoxifen with soy products, ask your doctor. Although not established, there is some indication that soy compounds may increase breast tumor development.

 It is critical to inform your doctor about any additional drugs you are taking. It also includes vitamins and herbs. Stop drinking alcohol.

Letro and Nolva Together for Gyno 

When Letrozole is used in combination with Nolvadex, both medications make the other less efficient. Combining these medications is not advised for PCT.

According to one study, when Letrozole is combined with Nolvadex, it reduces blood plasma concentrations. 

So you should either choose Nolvadex or Letrozole once a time. Otherwise, it will cause severe damage to your health.

Letro and Nolva for Gyno

Final Thoughts (70-90 w)

Nolvadex is not recommended for lowering or regulating estrogen levels throughout a cycle. If 20 mg per day does not prevent gynecomastia, you will require an AI. 

If you cannot manage the water retention with this amount, go with Letrozole.  

Many steroids can increase high blood pressure, and water retention and liver problems. For example, Dianabol can be bad for the liver. Nonetheless, water retention must be maintained with a balanced diet, particularly carbs. 

Overeating causes water retention, which flavoring steroids can exacerbate. Control your food and estrogen levels with SERM, and you’ll be OK. Nolvadex is recommended for persons who might benefit from losing a little water retention.


Can you drink alcohol while taking Letrozole?

No, you can’t take alcohol while taking letrozole. It raises the risk of nausea and headaches. The drugs can produce these symptoms alone. So when combined, these concerns can become more apparent. Besides, Alcohol is a well-known depressant, health risk, liver stressor, and other harmful effects.

How  Quickly does Nolvadex work?

Nolvadex will begin to act within hours. Try to avoid using it at the last minute. Otherwise, it will take a few days to notice the benefits. You should start running it at the start of your cycle.

Does Nolvadex Cause Baldness?

Nolvadex does not cause baldness. However, it can cause hair thinning in certain people. A diminished libido causes hair loss. It is prevalent in postmenopause and in the context of reduced estrogen.


So, what do you think after reading this article? In your opinion, which medicine is recommended by you between letro and nolva for gyno.

Furthermore, make sure that before using any drugs, you should go to the doctor before using any medications. They can guide us and give a brief overview.

And always heat healthy, live healthy, and do some extra miles in the gym. 

Best of luck!

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